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Basophilic stippling: a lead to the diagnosis

Basophilic stippling: a lead to the diagnosis
#00012893
Author: Javier Munoz and Yue Guo
Category: Underproduction Anemias > Acquired aplastic anemia > Benzene/environmental toxins
Published Date: 06/07/2013

A 44-year-old male presented with chronic abdominal pain that prompted multiple previous hospitalizations with negative assessments. The patient had a past history of moderate alcohol consumption but none in the past 20 years. There was no occupational exposure. Laboratory tests showed microcytic anemia (hemoglobin 6.6 mg/dL, mean corpuscular volume 66.8 fL) with normal iron studies and basophilic stippling on the peripheral smear (panel A). Further history disclosed a retained bullet fragment in his right thigh 2 years previously. Radiographic views of his right thigh affirmed several metallic bullet fragments and posttraumatic soft tissue calcification and ossification. Computed tomography with 3-D reconstruction (panel B) showed a large calcified mass of the thigh, consistent with a complex hematoma. Lead levels were as high as 306 µg/dL. The patient was started on intramuscular EDTA for chelation. The bullet fragments were surgically removed without complications .