Show Main Menu +
  • COLLECTION
    Images of peripheral blood and/or bone marrow of blood disorders and normal hematopoiesis.
  • ATLAS
    Normal and abnormal blood cells
  • REFERENCE CASES
    Complete cases of common blood disorders (peripheral blood, bone marrow, and diagnostic studies).
  • UPLOAD IMAGES
< Continue browsing

Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria (PNH) clone

Author:  Katherine Calvo, MD, PhD, 09/20/2015
Category: Underproduction Anemias > Acquired aplastic anemia > PNH (clonal)
Published Date: 01/26/2016
     
Share Image
Views: 4104
 Downloads: 68  
Size: 0.35 MB
 23 year old male presented with severe pancytopenia (WBC 2.1 K/uL, Hb 4.6 g/dL, Plt 10 K/uL , ANC 0.39 K/uL, ARC 16.9 K/uL).
Peripheral Blood

The peripheral blood shows pancytopenia.

No Image is attached in this Figure.
Bone Marrow aspirate

Bone marrow aspirate showed paucicellular marrow particles. 

No Image is attached in this Figure.
Bone Marrow Biopsy

Bone marrow biopsy showed less than 10% cellularity with severe trilineage hypoplasia consistent with aplastic anemia. 

No Image is attached in this Figure.
Identification of large PNH clone by flow cytometry.

Identification of large PNH clone by flow cytometry.

Granulocytes (red) in peripheral blood derived from PNH clone are

negative for GPI-linked proteins and FLAER.

No Image is attached in this Figure.