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B-ALL, BCR-ABL1+

Author:  Katherine Calvo, MD, PhD; Gordana Raca, Ph D, 09/21/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma > B-Lymphoblastic Leukemia/Lymphoma, with recurrent genetic abnormalities > B-Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34;q11.2); BCR-ABL1
Published Date: 07/09/2018
     
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67 year old female presented with pancytopenia and blasts seen on smear.

Peripheral Blood

Pancytopenia and blasts are seen on the peripheral blood smear

ALL-Ph-CD-13-positive-peripheral-blood
#00060060
 
Aspirate

Aspirate was  hemodilute.  Biopsy touch prep showed numerous blasts. 

Cytogenetic analysis revealed presence of Philadelphia chromosome (p190).  

ALL-Ph-CD-13-positive-Aspirate
#00060056
 
Biopsy

The bone marrow biopsy showed extensive re-population by blasts.

ALL-Ph-CD-13-positive-biopsy
#00060058
 
Special Stains

Special stains and higher power view of blast populaton

ALL-Ph-CD-13-positive-special-stains
#00060057
 
Flow cytometry

Flow cytometric analysis, peripheral blood.  The blasts (red) are positive for CD19, CD34, CD13, CD10, HLA-DR; and are negative for CD117, CD33, CD20, CD45 and surface light chains => B-ALL with CD13 expression.

ALL-Ph-CD-13-positive-flow-cytometry
#00060059
 
Cytogenetics 46,XX,t(9;22)(q34;q11.2)
Cytogenetics-ALL-Ph
#00060363