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B-ALL, BCR-ABL1+

Author:  Katherine Calvo, MD, PhD; Gordana Raca, Ph D, 09/21/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma > B-Lymphoblastic Leukemia/Lymphoma, with recurrent genetic abnormalities > B-Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34;q11.2); BCR-ABL1
Published Date: 07/09/2018
     
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67 year old female presented with pancytopenia and blasts seen on smear.

Peripheral Blood

Pancytopenia and blasts are seen on the peripheral blood smear

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Aspirate

Aspirate was  hemodilute.  Biopsy touch prep showed numerous blasts. 

Cytogenetic analysis revealed presence of Philadelphia chromosome (p190).  

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Biopsy

The bone marrow biopsy showed extensive re-population by blasts.

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Special Stains

Special stains and higher power view of blast populaton

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Flow cytometry

Flow cytometric analysis, peripheral blood.  The blasts (red) are positive for CD19, CD34, CD13, CD10, HLA-DR; and are negative for CD117, CD33, CD20, CD45 and surface light chains => B-ALL with CD13 expression.

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Cytogenetics 46,XX,t(9;22)(q34;q11.2)
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