Acute Megakaryoblastic Leukemia

Author:  Elizabeth L. Courville, MD, 09/23/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > AML not otherwise specified > Acute megakaryoblastic leukemia
Published Date: 02/25/2016
Acute Megakaryoblastic Leukemia 
•       Four-year-old male with fatigue, early satiety, increased bruising for past month, and pallor for 2 weeks
•       No stigmata or history of Down syndrome
–      CBC at diagnosis: WBC 2,360/μL, Hgb 8 g/dL, Hct 22.3%, MCV 82.7, RDW 19.3%, Platelets 19,000/μL
–      Differential count: Blasts 21%, Monocytes 7%, Lymphocytes 19%, Neutrophils 62%, Eosinophils 1%
•       Bone marrow aspirate, dry tap
Peripheral Blood

Peripheral blood showed circulating blasts and pancytopenia.  

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Marrow Biopsy

Biopsy showed a packed marrow and the aspirate was a dry tap. 

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Flow cytometry

Flow cytometry

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