Peripheral Blood
6 year old female with anemia and thrombocytopenia with blasts on peripheral smear
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Biopsy
Bone marrow core biopsy low power, hypocellular for age
Bone marrow core biopsy high power, reduced normal elements and increased blasts.
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Aspirate
Bone marrow aspirate shows blasts
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Special Stains
CD 3 positive on special stains
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Flow Cytometry
Flow cytometric analysis of the marrow aspirate identifies 77% abnormal T-lineage blasts:
CD3+ (cytoplasmic and surface), CD5+, CD7+, HLA-DR+, CD34-, CD8-, CD4-, CD19-, and TdT-.
Diagnosis: T lymphoblastic leukemia
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