PNH Peripheral blood
28 year old male with pancytopenia (WBC 3.3 K/uL, Hb 7.8 g/dL, Plt 34 K/uL, ANC 1.40 K/uL, ARC 145 K/uL). Peripheral blood shows pancytopenia matching his counts.
PNH Aspirate
Marrow aspirate showed erythroid hyperplasia with occasional nuclear budding consistent with stressed erythropoiesis. Differential: 1% blasts 18% myeloid, 62% erythroid, 15% lymphocytes, 1% eosinophils, 2% monocytes, 1% plasma cells
Marrow Core Biopsy
Bone marrow core biopsy is mildly hypercellular with erythroid hyperplasia, decreased megakaryocytes and myeloid precursors, and no increase in CD34 positive cells or blasts.
Flow cytometry
Identification of large PNH clone by flow cytometry.
Granulocytes (red) in peripheral blood derived from PNH clone are
negative for GPI-linked proteins and FLAER.
