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B-ALL relapse

Author:  Katherine Calvo, MD, PhD, 01/27/2016
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma > B-Lymphoblastic Leukemia/Lymphoma, not otherwise specified
Published Date: 07/09/2018
     
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This is a 22-year-old male with history of B-lymphoblastic leukemia presenting with pancytopenia.

Peripheral Blood Smear Blasts were seen on the peripheral smear.
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Marrow Aspirate The aspirate shows blasts and very rare normal elements.
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Marrow Biopsy
Normal marrow elements are replaced by blasts with high N:C ratio, fine chromatin,
and inconspicuous nucleoli.   Mitoses are present.
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Low power biopsy Bone marrow core biopsy is markedly hypercellular
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Immunohistochemistry stains Immunohistochemistry stains on core biopsy.  The blasts were positive for CD34, CD79a, TdT, and CD10
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