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Refractory Cytopenia of Childhood

Author:  Katherine Calvo, MD, PhD, 02/21/2016
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myelodysplastic Syndromes (MDS) > Refractory cytopenia of childhood (provisional)
Published Date: 02/25/2016
     
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8 year old female was evlauated for  pancytopenia.  Cytogenetic analysis showed and abnormal karyotype involving der(5)t(1;5). 

Low power view biopsy

8 year old female with pancytopenia.  Markedly hypocellular bone marrow for age.

Cytogenetic analysis showed and abnormal karyotype involving der(5)t(1;5). 

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Higher power views of biopsy

Focal areas of the core biopsy show presence of megakaryocytes, and erythroid and myeloid precursors with erythroid predominance.

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CD61 immunohistochemistry stain

CD61 immunohistochemistry highlights atypical megakaryocytes with micromegakaryocytes

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CD34 stain

Immunohistochemistry for CD34 shows scattered positive cells, overall less than 5%.

No evidence of increased blasts.

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Marrow Aspirate

Aspirate.  No increase in blasts.  Focal area with myelopoieis and erythropoiesis.

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Marrow Aspirate

Paucicelluar aspirate with atypical/dysplastic cell

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