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Acute myeloid leukemia with mutated NPM1

Author:  Elizabeth L. Courville, MD, 09/16/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with mutated NPM1
Published Date: 02/25/2016
     
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30 year old male presents with fatigue and leukocytosis.  
Blasts comprised the majority (approximately 95%) of circulating peripheral blood and marrow leukocytes. An NPM1 exon 12 frameshift mutation was detected by PCR.

Blasts in AML mutated NPM1

There is a marked leukocytosis with blasts comprising the majority of circulating peripheral blood leukocytes. The blasts are medium to large in size and have an elevated nuclear:cytoplasmic ratio. The nuclear chromatin is fine and there are prominent nucleoli. Frequent blasts show indented or “cup-shaped” nuclear contours. 

 

Blasts comprised the majority (approximately 95%) of circulating peripheral blood and marrow leukocytes. An NPM1 exon 12 frameshift mutation was detected by PCR. 

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