Current WHO 2016 Classification of EBV+ T-cell and NK-cell Proliferations
The image below depicts the current 2016 WHO classification of EBV+ T-cell and NK-cell proliferations.
Figure 1: Clinical Images in Hydroa Vacciniforme-like Lymphoproliferative Disorder
Examination demonstrated multiple erythematous papules on the face and scalp associated with pain, itching, crusting and scarring.
Figure 2: H&E in Hydroa Vacciniforme-like Lymphoproliferative Disorder
Features seen in the images below:
- Epidermal degeneration with spongiotic vesiculation
- Lymphoid infiltration in dermis and subcutaneous tissue
- Periadnexal and perivascular infiltration by small-to-medium sized neoplastic cells without significant atypia
Figure 3: CD3, CD4, & CD8 in Hydroa Vacciniforme-like Lymphoproliferative Disorder
CD3 shows scattered T-cells comprising an admixture of CD4 and CD8 T-cells. Usually CD8 T-cells are more predominant.
Figure 4: TCRB, KI-67 and TIA1 in Hydroa Vacciniforme-like Lymphoproliferative Disorder
TCRB stains shows scattered CD3+ T-cells while Ki-67 shows low proliferation and numerous cytotoxic cells are noted.
Figure 5: EBER in Hydroa Vacciniforme-like Lymphoproliferative Disorder
Numerous EBV+ cells are noted throughout. CD30 is often positive in the EBV infected cells. The EBV is usually in latency phase II and is EBV-LMP negative. The EBV is clonal by long terminal repeat analysis.
